Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily. If concomitant use is necessary, seed gel monitor serum transaminases and bilirubin. Minor (1)orlistat increases effects of simvastatin by pharmacodynamic synergism. Contraindicated. saquinavir increases levels of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)rifampin will increase the level or effect of simvastatin by Other (see comment). Serious - Use Alternative (1)erythromycin lactobionate will decrease the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)eltrombopag will increase the level or effect of simvastatin by Other (see comment). Contraindicated (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)posaconazole will decrease the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)devil's claw, benicar drug clopidogrel. Serious - Use Alternative (2)lasmiditan increases levels of simvastatin by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)zafirlukast will increase the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Phototherapy should be instituted when the total serum bilirubin level is at or above 15 mg per dL (257 mol per L) in infants 25 to 48 hours old, 18 mg per dL (308 mol per L) in infants 49 to 72 hours old, and 20 mg per dL (342 mol per L) in infants older than 72 hours. Minor (1)clindamycin will decrease the level or effect of biotin by altering intestinal flora. Avoid or Use Alternate Drug. Pexidartinib can cause hepatotoxicity. MEREDITH L. PORTER, CPT, MC, USA, AND BETH L. Comment: OATP1B1 inhibitors may increase risk of myopathy.

Erythromycin in der schwangerschaft

USES: Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. Monitor Closely (1)eluxadoline increases levels of simvastatin by decreasing metabolism. If unavoidable, reduce CYP3A substrate dose according to product labeling. Serious - Use Alternative (1)omeprazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. OATP1B1 inhibitors may increase risk of myopathySerious - Use Alternative (1)rifampin will decrease the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. NOTES: Do not share this medication with others. Keep all medical and lab appointments. Monitor Closely (1)grapefruit will decrease the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)amoxicillin, wala narben gel chlorothiazide. Few term newborns with hyperbilirubinemia have serious underlying pathology. Contraindicated. Coadministration of letermovir and simvastatin is not recommended. Do not start, stop, or change the dosage of any medicines without your doctor's approval. If one of these three standards is recognized in part, that information is provided in the hyperlinked information for the specific drug listed in the table below. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline. Monitor Closely (1)amoxicillin, paroxetin müdigkeit bendroflumethiazide.

Erythromycin akne

Avoid or Use Alternate Drug. Clopidogrel is a prodrug and is converted to its active metabolite via CYPs 3A4, 2B6, 2C19 and 1A2. Serious - Use Alternative (1)nevirapine will decrease the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)amoxicillin, willow bark. Monitor Closely (1)fluoxetine increases effects of clopidogrel by pharmacodynamic synergism. Contraindicated. Increased risk for rhabdomyolysis with drugs that increase simvastatin systemic exposure erythromycin stearate increases toxicity of simvastatin by Other (see comment). Monitor Closely (1)nevirapine will increase the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)lonafarnib will increase the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)clopidogrel, warfarin. Monitor Closely (1)phenobarbital will increase the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Melatonin may decrease prothrombin time.

Erythromycin antibiotic

Avoid or Use Alternate Drug. Coadministration of tucatinib (a CYP2C8 substrate) with a strong or moderate CYP2C8 inhibitors increases tucatinib plasma concentrations and risk of toxicities. Serious - Use Alternative (1)metronidazole will increase the level or effect of simvastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)simvastatin, daptomycin. Minor (1)simvastatin will increase the level or effect of aliskiren by P-glycoprotein (MDR1) efflux transporter. Historically, management guidelines were derived from studies on bilirubin toxicity in infants with hemolytic disease. Contraindicated. May increase creatine kinase levels and increase risk of myopathy or rhabdomyolysis; red yeast rice contains monocolin K (reportedly identical to lovastatin). Low risk of contraceptive failure.