Ashwagandha is considered relatively safe for most people. IV. The effect of total alkaloids on the smooth muscles. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Pretreatment with Withania somnifera (WS) showed significance protection against stress induced gastric ulcers. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. A popular Ayurvedic herb, ashwagandha is often used in formulations prescribed for stress, strain, fatigue, pain, skin diseases, diabetes, gastrointestinal disease, rheumatoid arthritis, and epilepsy (1). Nov 30;2021:8254344. View abstract. One study in 80 healthy men and women showed that taking 600 mg of ashwagandha daily for 8 weeks was safe and did not cause any adverse health effects in participants (25). K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Solanaceae) is commonly known as “Indian Winter cherry” or “Indian Ginseng”. Ghosal S, Lal J, Srivastava R, and et al. Ashwagandha might cause allergic reactions in people who are allergic to nightshades. It is used for various kinds of disease processes and specially as a nervine tonic. It enhances the function of the brain and nervous system and improves the memory. Moreover, I’ve made a couple of videos on my YouTube channel discussing the benefits of ashwagandha and other similar supplements. Chandrasekhar K, Kapoor J, Anishetty S. Cancer Lett. 8-16-1995;95(1-2):189-193. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. J Ethnopharmacol 1999;64:91-3. View abstract. Also, those with hormone-sensitive prostate cancer and those taking certain medications, such as benzodiazepines, anticonvulsants, or barbiturates, should avoid taking ashwagandha (26).

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Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. It also improves the white cell count (WBC) and function, scopoderm pflaster beipackzettel which are depleted in the chemotherapeutic treatment of cancer. Withania somnifera extract. Its effect on arterial blood pressure in anaesthetized dogs. Large scale clinical studies are needed to prove the clinical efficacy of this herb, specially in stress related diseases, neuronal disorders and cancers. Dongre S, Langade D, Bhattacharyya S. For example, a study in 50 adults ages 65–80 found that taking 600 mg of ashwagandha root per day for 12 weeks significantly improved sleep quality and mental alertness upon waking compared with a placebo treatment (23). Nutrients. 2020;12(4):1119. View abstract. There are a slew of herbs that have become buzzy over the last few years. Certain compounds found in ashwagandha may have antioxidant properties for the brain—and that can help with your overall cognitive function, Zellner says. Although known for its many benefits, this article sheds some light on ashwagandha side effects on pregnancy, heart, weight gain and much more. As per studies, gel express ashwagandha has been shown to help reduce blood sugar levels. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. J Ethnopharmacol. 2001;75(2-3):165-168. VO2 max is the maximum amount of oxygen a person can use during intense activity. This will help them manage your care and keep you safe. Just check in with your doctor before trying it out, to be safe. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. WS also acts as an immunomodulator and hence can enhance life span of cancer patients, where lowered immunity states of the patient are the cause of concern. Pregnant or breastfeeding women should avoid ashwagandha tea. Ashwagandha might cause sleepiness and slowed breathing. Malhotra, C. L., cr2032 lithium battery rechargeable Mehta, V. L., Prasad, K., and Das, P. Anti-arthritic effects are attributed to cyclooxygenase (COX) inhibition.

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Acta Oncol. 1996;35(1):95-100. View abstract. However, more research is needed. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Alkaloids, steroidal lactones, saponins, and withanolides are considered the biologically active components of ashwagandha. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. This information may not fit your specific health circumstances. Animal studies have shown that WA may also help reduce levels of inflammatory proteins such as interleukin-10 (IL-10) (18). Phytother.Res 2010;24(1):129-135. The aerial parts of Withania somnifera yielded 5-dehydroxy withanolide-R and withasomniferin-A (Atta-ur-Rahman et al., 1991). Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Supplements are stronger than the herbs you would use in cooking. Low VO2 max is associated with increased mortality risk, while higher VO2 max is associated with a lower risk of heart disease (8). It prevented urethane-induced lung-adenomas in mice.

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Often, it’s best to check with your doctor if it makes sense for you to begin taking Ashwagandha. It is one of the best nervine tonics of Ayurveda, the most ancient system of Medical Sciences. I’ve been taking ashwagandha for about three years now, starting with liquid ashwagandha and more recently, consuming the supplement in pill form. In a small study of breast cancer patients, ashwagandha alleviated chemotherapy-induced fatigue and improved quality of life (31).